In Season 11, Sanctification sits right at the sharp end of item crafting, and it feels more like signing a contract than pressing a random upgrade button, so before you rush off to click on the first portal you see or think about the best place to buy diablo 4 runes, you need to remember that once you sanctify an item it is locked forever, no redo, no small fixes, and no sneaky re-roll to bail you out if you mess it up.
Save time, skip the grind — get what you need now from https://www.u4gm.com/diablo-4/items